A study of 15 population-based cohorts, totalling 56,351 individuals, suggests that there is a correlation between inflammation as measured by elevated C-reactive protein (CRP) and interleukin-6 (IL-6) and a specific sub-group of symptoms of depression. The inflammation cluster consisted of four physical symptoms: changes in appetite, felt everything was an effort, loss of energy, sleep problems; and one cognitive symptom: little …
Lithium Weight Gain
Does lithium cause weight gain? It is remarkable how difficult it can be to find out the answers to relatively simple questions on the internet. One of my patients asked me about the effect of lithium on weight and, while I was explaining my experience with many hundreds of patients treated with lithium (not a significant cause of weight gain …
“Biggest Loser” Misunderstandings
Last week on most everybody in my practice who has ever struggled with weight loss came in talking about the widely reported results of a follow-up study to the TV show “Biggest Loser.” And almost everybody’s conclusion from the media coverage was that it seemed the media was suggesting that it was a waste of time trying to lose weight. Most …
Weight Gain with Atypical Antipsychotics – A Review of Strategies
Many antipsychotics, especially some atypical or second generation antipsychotics, like olanzapine (Zyprexa) or quetiapine (Seroquel), cause significant weight gain, as well as insulin resistance (diabetes) and elevated lipids. What to do if the medication is helping (much more than alternatives) but the patient is developing these serious adverse effects? Two recent articles review the literature on strategies for managing these …