Depression, Anhedonia, Glutamate, and Inflammation

Peter ForsterBasic Science, Major Depression, Psychobiology

That depression may be linked to alterations in glutamate circuits is suggested by the observation that ketamine (which is an NMDA glutamate receptor antagonist) may rapidly reverse depression in some patients. Depression has also been found to be associated in some people with various markers for inflammation (c reactive protein, tumor necrosis factor, interleukin 1 beta, and interleukin 6). As …